Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

G Lazzari, P Couvreur, S Mura - Polymer Chemistry, 2017 - pubs.rsc.org
The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …

Development of highly efficient nanocarrier-mediated delivery approaches for cancer therapy

K Jeong, CS Kang, Y Kim, YD Lee, IC Kwon, S Kim - Cancer letters, 2016 - Elsevier
Nanocarriers (NCs) are a group of nano-sized vehicles devised to deliver drugs to targeted
malignant tissues or organs that provide remarkably improved targeting efficiency and …

Blurring the role of oligonucleotides: spherical nucleic acids as a drug delivery vehicle

X Tan, X Lu, F Jia, X Liu, Y Sun… - Journal of the …, 2016 - ACS Publications
Nucleic acids are generally regarded as the payload in gene therapy, often requiring a
carrier for intracellular delivery. With the recent discovery that spherical nucleic acids enter …

Monodisperse cylindrical micelles and block comicelles of controlled length in aqueous media

A Nazemi, CE Boott, DJ Lunn, J Gwyther… - Journal of the …, 2016 - ACS Publications
Cylindrical block copolymer micelles have shown considerable promise in various fields of
biomedical research. However, unlike spherical micelles and vesicles, control over their …

A robust strategy for preparation of sequential stimuli-responsive block copolymer prodrugs via thiolactone chemistry to overcome multiple anticancer drug delivery …

W Ke, W Yin, Z Zha, JF Mukerabigwi, W Chen, Y Wang… - Biomaterials, 2018 - Elsevier
Block copolymer prodrugs (BCPs) have attracted considerable attentions in clinical
translation of nanomedicine owing to their self-assembly into well-defined core-shell …

Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system

S Jafarzadeh-Holagh, S Hashemi-Najafabadi… - Journal of colloid and …, 2018 - Elsevier
Nanocarrier-based drug delivery systems have been explored extensively in cancer therapy.
Among the vast number of different nanocarrier systems applied to deliver …

Ring-opening polymerization of epoxides: facile pathway to functional polyethers via a versatile organoaluminum initiator

CG Rodriguez, RC Ferrier Jr, A Helenic… - Macromolecules, 2017 - ACS Publications
We report a new class of organoaluminum-based initiator for anionic ring-opening
polymerization of epoxides that is simple to synthesize from readily available precursors …

Controlling and monitoring intracellular delivery of anticancer polymer nanomedicines

C Battistella, HA Klok - Macromolecular bioscience, 2017 - Wiley Online Library
Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics.
Polymer conjugates and other polymer‐based nanocarriers allow to increase plasma half …

Off‐Stoichiometric Thiol‐Ene Chemistry to Dendritic Nanogel Therapeutics

Y Zhang, OCJ Andrén, R Nordström… - Advanced Functional …, 2019 - Wiley Online Library
A novel platform of dendritic nanogels is herein presented, capitalizing on the self‐assembly
of allyl‐functional polyesters based on dendritic‐linear‐dendritic amphiphiles followed by …

Pendant/bridged/mesoporous silsesquioxane nanoparticles: Versatile and biocompatible platforms for smart delivery of therapeutics

A Noureddine, CJ Brinker - Chemical Engineering Journal, 2018 - Elsevier
Silsesquioxane nanoparticles are composed of repetitive organosilica fragments in their
frameworks and are now recognized to have outstanding functional fertility. Depending on …