Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia
RK Jain - Cancer cell, 2014 - cell.com
Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment.
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
However, these agents, intended to block tumors' blood supply, may cause hypoxia, which …
The genetic landscape and possible therapeutics of neurofibromatosis type 2
Abstract Neurofibromatosis type 2 (NF2) is a genetic condition marked by the development
of multiple benign tumors in the nervous system. The most common tumors associated with …
of multiple benign tumors in the nervous system. The most common tumors associated with …
Secreted factors from human vestibular schwannomas can cause cochlear damage
Vestibular schwannomas (VSs) are the most common tumours of the cerebellopontine
angle. Ninety-five percent of people with VS present with sensorineural hearing loss …
angle. Ninety-five percent of people with VS present with sensorineural hearing loss …
New developments in neurofibromatosis type 2 and vestibular schwannoma
Abstract Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder
characterized by the development of multiple nervous system tumors due to mutation in the …
characterized by the development of multiple nervous system tumors due to mutation in the …
Hearing loss and vestibular schwannoma: new insights into Schwann cells implication
T Mohamed, V Melfi, A Colciago, V Magnaghi - Cell Death & Disease, 2023 - nature.com
Hearing loss (HL) is the most common and heterogeneous disorder of the sensory system,
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …
with a large morbidity in the worldwide population. Among cells of the acoustic nerve (VIII …
Sporadic vestibular schwannoma size and location do not correlate with the severity of hearing loss at initial presentation
A Brown, S Early, S Vasilijic, KM Stankovic - Frontiers in oncology, 2022 - frontiersin.org
Vestibular schwannoma (VS) is a non-malignant intracranial neoplasm arising from the
vestibular branch of the 8th cranial nerve; sensorineural hearing loss (SNHL) is the most …
vestibular branch of the 8th cranial nerve; sensorineural hearing loss (SNHL) is the most …
Biomarkers in vestibular schwannoma–associated hearing loss
L Lassaletta, M Calvino, JM Morales-Puebla… - Frontiers in …, 2019 - frontiersin.org
Vestibular schwannomas (VSs) are benign tumors composed of differentiated neoplastic
Schwann cells. They can be classified into two groups: sporadic VS and those associated …
Schwann cells. They can be classified into two groups: sporadic VS and those associated …
Extracellular vesicles derived from human vestibular schwannomas associated with poor hearing damage cochlear cells
Background Vestibular schwannoma (VS) is a tumor of the vestibular nerve that transmits
balance information from the inner ear to the brain. Sensorineural hearing loss occurs in …
balance information from the inner ear to the brain. Sensorineural hearing loss occurs in …
Current understanding of hearing loss in sporadic vestibular schwannomas: a systematic review
J Gan, Y Zhang, J Wu, D Lei, F Zhang, H Zhao… - Frontiers in …, 2021 - frontiersin.org
Objective Hearing loss is the most common initial symptom in patients with sporadic
vestibular schwannomas (SVS). Hearing preservation is an important goal of both …
vestibular schwannomas (SVS). Hearing preservation is an important goal of both …
Mechanisms of hearing loss in neurofibromatosis type 2
Introduction Patients with neurofibromatosis type 2 (NF2) develop bilateral cochleovestibular
schwannomas (CVSs) that cause binaural deafness in most individuals. Hearing loss occurs …
schwannomas (CVSs) that cause binaural deafness in most individuals. Hearing loss occurs …