To join or not to join: decision points along the pathway to double-strand break repair vs. chromosome end protection
SM Ackerson, C Romney, PL Schuck… - Frontiers in Cell and …, 2021 - frontiersin.org
The regulation of DNA double-strand breaks (DSBs) and telomeres are diametrically
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …
opposed in the cell. DSBs are considered one of the most deleterious forms of DNA damage …
Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair
Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 …
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration
Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular
disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We …
disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We …
Telomere maintenance and the DNA damage response: a paradoxical alliance
A Harman, TM Bryan - Frontiers in Cell and Developmental Biology, 2024 - frontiersin.org
Telomeres are the protective caps at the ends of linear chromosomes of eukaryotic
organisms. Telomere binding proteins, including the six components of the complex known …
organisms. Telomere binding proteins, including the six components of the complex known …
Pan-cancer analyses identify the CTC1-STN1-TEN1 complex as a protective factor and predictive biomarker for immune checkpoint blockade in cancer
The CTC1-STN1-TEN1 (CST) complex plays a crucial role in telomere replication and
genome stability. However, the detailed mechanisms of CST regulation in cancer remain …
genome stability. However, the detailed mechanisms of CST regulation in cancer remain …
Pol α-primase dependent nuclear localization of the mammalian CST complex
JM Kelich, H Papaioannou, E Skordalakes - Communications Biology, 2021 - nature.com
The human CST complex composed of CTC1, STN1, and TEN1 is critically involved in
telomere maintenance and homeostasis. Specifically, CST terminates telomere extension by …
telomere maintenance and homeostasis. Specifically, CST terminates telomere extension by …
Cooperative interaction of CST and RECQ4 resolves G‐quadruplexes and maintains telomere stability
T Li, M Zhang, Y Li, X Han, L Tang, T Ma, X Zhao… - EMBO …, 2023 - embopress.org
Abstract Human CST (CTC1‐STN1‐TEN1) is a ssDNA‐binding complex that interacts with
the replisome to aid in stalled fork rescue. We previously found that CST promotes telomere …
the replisome to aid in stalled fork rescue. We previously found that CST promotes telomere …
Suppression of CTC1 inhibits hepatocellular carcinoma cell growth and enhances RHPS4 cytotoxicity
A Kipcak, S Sezan, O Karpat, E Kaya, S Baylan… - Molecular Biology …, 2024 - Springer
Background Although DNA repair mechanisms function to maintain genomic integrity, in
cancer cells these mechanisms may negatively affect treatment efficiency. The strategy of …
cancer cells these mechanisms may negatively affect treatment efficiency. The strategy of …
Human CST complex restricts excessive PrimPol repriming upon UV induced replication stress by suppressing p21
DNA replication stress, caused by various endogenous and exogenous agents, halt or stall
DNA replication progression. Cells have developed diverse mechanisms to tolerate and …
DNA replication progression. Cells have developed diverse mechanisms to tolerate and …