Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

International union of basic and clinical pharmacology. CII: pharmacological modulation of H2S levels: H2S donors and H2S biosynthesis inhibitors

C Szabo, A Papapetropoulos, EH Ohlstein - Pharmacological reviews, 2017 - Elsevier
Over the last decade, hydrogen sulfide (H 2 S) has emerged as an important endogenous
gasotransmitter in mammalian cells and tissues. Similar to the previously characterized …

Hydrogen sulfide-releasing therapeutics: translation to the clinic

JL Wallace, D Vaughan, M Dicay… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Shortly after the discovery of the role of hydrogen sulfide (H2S) in many
physiological and pathological processes, attempts were made to develop novel …

[HTML][HTML] Disease-modifying effects of COX-2 selective inhibitors and non-selective NSAIDs in osteoarthritis: a systematic review

K Nakata, T Hanai, Y Take, T Osada, T Tsuchiya… - Osteoarthritis and …, 2018 - Elsevier
Osteoarthritis (OA) is a potentially disabling disease whose progression is dependent on
several risk factors. OA management usually involves the use of non-steroidal anti …

Molecular hydrogen: Potential in mitigating oxidative-stress-induced radiation injury

B Kura, AK Bagchi, PK Singal… - Canadian Journal of …, 2019 - cdnsciencepub.com
Uncontrolled production of oxygen and nitrogen radicals results in oxidative and nitrosative
stresses that impair cellular functions and have been regarded as causative common …

Nonsteroidal anti‐inflammatory therapy: a journey toward safety

C Pereira‐Leite, C Nunes, SK Jamal… - Medicinal research …, 2017 - Wiley Online Library
The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …

Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes

X Fang, J Wang, C Ye, J Lin, J Ran, Z Jia… - Nature …, 2024 - nature.com
Excessive oxidative response, unbalanced immunomodulation, and impaired mesenchymal
stem cell function in periodontitis in diabetes makes it a great challenge to achieve …

Anti-inflammatory effect of ATB-352, a H2S− releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats

E Gugliandolo, R Fusco, R D'Amico, A Militi… - Pharmacological …, 2018 - Elsevier
Periodontal disease is the most common cause of tooth loss in humans, is an inflammatory
disease initiated by oral microbial biofilm. Given the involvement of the inflammatory …

Gasotransmitters and the immune system: Mode of action and novel therapeutic targets

P Fagone, E Mazzon, P Bramanti, K Bendtzen… - European Journal of …, 2018 - Elsevier
Gasotransmitters are a group of gaseous molecules, with pleiotropic biological functions.
These molecules include nitric oxide (NO), hydrogen sulfide (H 2 S), and carbon monoxide …