The PI3K/AKT pathway—The potential key mechanisms of traditional Chinese medicine for stroke

C Gu, Q Zhang, Y Li, R Li, J Feng, W Chen… - Frontiers in …, 2022 - frontiersin.org
Stroke is associated with a high disability and fatality rate, and adversely affects the quality
of life of patients and their families. Traditional Chinese Medicine (TCM) has been used …

Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine

M Zhou, Y Hong, X Lin, L Shen, Y Feng - Journal of Ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance Chinese herbs have been used in China for thousands of
years and are also becoming popular in Western medicine. Formulae of traditional Chinese …

Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases

D Ran, W Hong, W Yan, W Mengdie - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance Geniposide (GE) is ubiquitous in nearly 40 species of
plants, among which Gardenia jasminoides J. Ellis has the highest content, and has been …

Protective effect of Xingnaojing injection on ferroptosis after cerebral ischemia injury in MCAO rats and SH-SY5Y cells

H Liu, N An, L Wang, Y Li, K Song, Y Sun… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Xingnaojing (XNJ) injection is a traditional Chinese
medicine injection with neuroprotective effect, which has been widely used in the treatment …

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms

X Zhang, K Liu, M Shi, L Xie, M Deng, H Chen… - Brain Research Bulletin, 2021 - Elsevier
Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex
Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both …

Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis

JY Chen, H Wu, H Li, SL Hu, M Dai, J Chen - International …, 2015 - Elsevier
The aim of this study was to explore the anti-inflammatory effects of Geniposide (GE), an
iridoid glycoside compound extracted from Gardenia jasminoides Ellis (GJ) fruit in adjuvant …

XingNaoJing injection ameliorates cerebral ischaemia/reperfusion injury via SIRT1-mediated inflammatory response inhibition

YM Zhang, XY Qu, LN Tao, JH Zhai, H Gao… - Pharmaceutical …, 2020 - Taylor & Francis
Context XingNaoJing injection (XNJ), extracted from a traditional compound Chinese
medicine Angong niuhuang pill, is well known for treating stroke in the clinic, but the specific …

Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology

D Li, X Li, X Zhang, J Chen, Z Wang, Z Yu, M Wu… - Chinese Medicine, 2024 - Springer
In recent years, the prevalence and fatality rates of atherosclerotic cardiovascular disease
have not only shown a consistent rise that cannot be ignored, but have also become a …

Therapeutic potential of genipin in central neurodegenerative diseases

Y Li, L Li, C Hölscher - CNS drugs, 2016 - Springer
Central neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's
disease (PD), are one of the biggest health problems worldwide. Currently, there is no cure …

Xingnaojing Injection Protects against Cerebral Ischemia Reperfusion Injury via PI3K/Akt‐Mediated eNOS Phosphorylation

YM Zhang, XY Qu, JH Zhai, LN Tao… - Evidence‐Based …, 2018 - Wiley Online Library
Xingnaojing (XNJ) injection, derived from traditional Chinese medicine formulation, has a
protective effect against stroke, but the underlying mechanism is unclear, which severely …