Early brain development, from the embryonic period to infancy, is characterized by rapid
structural and functional changes. These changes can be studied using structural and …

Regulation of the cerebral circulation relies on the complex interplay between
cardiovascular, respiratory, and neural physiology. In health, these physiologic systems act …

Cerebrovascular pressure autoregulation is the physiologic mechanism that holds cerebral
blood flow (CBF) relatively constant across changes in cerebral perfusion pressure (CPP) …

Brain injury is one of the most consequential problems facing neonates, with many preterm
and term infants at risk for cerebral hypoxia and ischemia. To develop effective …

Background Impaired brain development in fetuses with congenital heart disease (CHD)
may result from inadequate cerebral oxygen supply in utero. Purpose To test whether fetal …

Background Intraoperative hypotension has been linked to poor postoperative neurological
outcomes. However, the definition of hypotension remains controversial in children. We …

Cerebral autoregulation reflects the ability of the brain to keep the cerebral blood flow (CBF)
relatively constant despite changes in cerebral perfusion pressure. It is an intrinsic …

Objective To compare outcomes at hospital discharge for preterm infants born before 29
weeks of gestation who had at least one episode of isolated hypotension during their first 72 …

Infants who undergo surgical procedures in the first few months of life are at a higher risk of
death or subsequent neurodevelopmental abnormalities. Although the pathogenesis of …

The brain is important for our survival and identity. It has high metabolic demands and is
therefore particularly vulnerable to hypoxia and hypoglycemia. To prevent injury and …