Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly. Dry AMD has unclear etiology and no treatment. Lipid-rich drusen are the hallmark …

In adult mammals, skin wounds typically heal by scarring rather than through regeneration.
In contrast," super-healer" Murphy Roths Large (MRL) mice have the unusual ability to …

Eye diseases are associated with visual impairment, reduced quality of life, and may even
lead to vision loss. The efficacy of available treatment of eye diseases is not satisfactory. The …

Purpose: Pathologic myopia (PM) is one of the primary causes of blindness. This study aims
to explore the possible relations between the composition of microRNA in vitreous …

Renal ion channel transport and electrolyte disturbances play an important role in the
process of functional impairment and fibrosis in the kidney. It is well known that there are …

Background Abdominal aortic aneurysm (AAA) is a complex vascular disease involving
expansion of the abdominal aorta. Extracellular matrix (ECM) degradation is crucial to AAA …

Articular cartilage allows the human body to buffer and absorb stress during normal
exercise. It is mainly composed of cartilage cells and the extracellular matrix and is …

Over the last two decades, the understanding of how dysregulated ion channels and
transporters are involved in carcinogenesis and tumor growth and progression, including …