Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling
molecules that poison surrounding cells, leading to various age-related diseases, including …

The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …

Ionizing radiation (IR) has been shown to play a crucial role in the treatment of glioblastoma
(GBM; grade IV) and non-small-cell lung cancer (NSCLC). Nevertheless, recent studies …

Background The E3 ubiquitin ligase HECTD3 is a homologue of the E6-related protein
carboxyl terminus, which plays a crucial role in biological processes and tumourigenesis …

Cellular senescence leads to decreased tissue regeneration and inflammation and is
associated with diabetes, neurodegenerative diseases, and tumorigenesis. However, the …

Although RNA interference (RNAi) therapy has emerged as a potential tool in cancer
therapeutics, the application of RNAi to glioblastoma (GBM) remains a hurdle. Herein, to …

DNA damage response (DDR) comprising DNA repair and cell-cycle checkpoint pathways,
is considered as a protective process that maintains the integrity of the genome. However …

Senescence is the arrest of cell proliferation and is a tumor suppressor phenomenon. In a
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme …

Poor prognosis and drug resistance in glioblastoma (GBM) can result from cellular
heterogeneity and treatment-induced shifts in phenotypic states of tumor cells, including …

Glioblastoma Multiforme (GBM) is the most aggressive brain tumor and classified as one of
the deadliest cancers. The current treatment plans for GBM remains to be ineffective …