Stressful experiences, both physical and psychological, that are overwhelming (ie,
inescapable and unpredictable), can measurably affect subsequent neuronal properties and …

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy,
childhood, adolescence, adulthood or aging, has an impact on brain structures involved in …

Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

Exposure to stressful events can be differently perceived by individuals and can have
persistent sequelae depending on the level of stress resilience or vulnerability of each …

The impact of stress on brain function is increasingly recognized. Various substances are
released in response to stress and can influence distinct neuronal circuits, but the functional …

Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …

Following the discovery of glucocorticoid receptors in the hippocampus and other brain
regions, research has focused on understanding the effects of glucocorticoids in the brain …

Chronic stress could trigger maladaptive changes associated with stress-related mental
disorders; however, the underlying mechanisms remain elusive. In this study, we found that …

Major depression (MD) is a common psychiatric disorder with a complex and multifactor
aetiology. Potential mechanisms associated with the pathogenesis of this disorder include …