Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Objective: Hmox1 (heme oxygenase-1) is a stress-induced enzyme that catalyzes the
degradation of heme to carbon monoxide, iron, and biliverdin. Induction of Hmox1 and its …

Subarachnoid hemorrhage (SAH) carries a 50% mortality rate. The extravasated
erythrocytes that surround the brain contain heme, which, when released from damaged red …

A diabetic foot ulcer (DFU) is one of the major complications of diabetes. Wound healing
under diabetic conditions is often impaired. This is in part due to the excessive oxidative …

ABSTRACT Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological
functions. YY1 either activates or represses gene transcription, depending on the stimuli …

Obesity has been a worldwide epidemic for decades. Despite the abundant increase in
knowledge regarding the etiology and pathogenesis of obesity, the prevalence continues to …

The prevalence of vascular disorders continues to rise worldwide. Parallel with that, new
pathophysiological pathways have been discovered, providing possible remedies for …

Gender difference is well recognized as a key risk factor for cardiovascular disease (CVD).
Estrogen, the primary female sex hormone, improves cardiovascular functions through …

Injury and loss of podocytes play vital roles in diabetic nephropathy progression. Emerging
evidence suggests autophagy, which is induced by multiple stressors including …