Autophagy: a potential therapeutic target of polyphenols in hepatocellular carcinoma

C Kiruthiga, KP Devi, SM Nabavi, A Bishayee - Cancers, 2020 - mdpi.com
Autophagy is a conserved biological phenomenon that maintains cellular homeostasis
through the clearing of damaged cellular components under cellular stress and offers the …

Mitigating the adverse effects of lead and cadmium heavy metals-induced oxidative stress by phytogenic compounds in poultry

R Ebrahimi, M Ebrahimi, M Shakeri - Poultry, 2023 - mdpi.com
Environmental pollution has increased over the past few decades, posing serious risks to all
biological systems, including the poultry sector. Oxidative stress in chickens caused by …

Toxicity of polystyrene nanoplastics and zinc oxide to mice

FN Estrela, ATB Guimarães, AP da Costa Araújo… - Chemosphere, 2021 - Elsevier
The toxicity of zinc oxide (ZnO NPs) and polystyrene nanoplastics (PS NaPs) has been
tested in different animal models; however, knowledge about their impact on mice remains …

Toxicity of polystyrene nanoplastics in Ctenopharyngodon idella juveniles: a genotoxic, mutagenic and cytotoxic perspective

ATB Guimarães, FN Estrela, PS Pereira… - Science of The Total …, 2021 - Elsevier
The increased contamination of surface water with plastic waste is proportional to the
increased consumption of products that use them as raw material. However, the impact of …

In silico and in vitro studies of mycotoxins and their cocktails; their toxicity and its mitigation by silibinin pre-treatment

VN Tran, J Viktorova, K Augustynkova, N Jelenova… - Toxins, 2020 - mdpi.com
Mycotoxins found in randomly selected commercial milk thistle dietary supplement were
evaluated for their toxicity in silico and in vitro. Using in silico methods, the basic …

Mutagenic, genotoxic and morphotoxic potential of different pesticides in the erythrocytes of Podocnemis expansa neonates

JSP de Oliveira, LG Vieira, WF Carvalho… - Science of the Total …, 2020 - Elsevier
Despite the damaging effects of pesticides glyphosate (Gly), atrazine (Atra) and fipronil (Fip)
on different organisms, the mutagenic, genotoxic and morphotoxic potential of testudine …

Antioxidant, anti-inflammatory, and multidrug resistance modulation activity of silychristin derivatives

J Viktorová, S Dobiasová, K Řehořová, D Biedermann… - Antioxidants, 2019 - mdpi.com
Silychristin A is the second most abundant compound of silymarin. Silymarin complex was
previously described as an antioxidant with multidrug resistance modulation activity. Here …

Sustained release of silibinin‐loaded chitosan nanoparticle induced apoptosis in glioma cells

M Alipour, M reza Bigdeli, H Aligholi… - … Research Part A, 2020 - Wiley Online Library
In this study, a chitosan nanoparticle formulation was synthesized for loading silibinin as a
sustained‐release drug system to evaluate its effects on apoptosis in C6 glioma cells. This …

Liposome-Based Silibinin for Mitigating Nonalcoholic Fatty Liver Disease: Dual Effects via Parenteral and Intestinal Routes

B Yan, X Zheng, Y Wang, J Yang, X Zhu… - ACS Pharmacology & …, 2023 - ACS Publications
Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological entity that is typically
characterized by intrahepatic ectopic steatosis. Nowadays, NAFLD has surpassed viral …

Silibinin and ellagic acid increase the expression of insulin receptor substrate 1 protein in ultraviolet irradiated rat skin

G Gorgisen, H Ozkol, Y Tuluce, A Arslan… - Biotechnic & …, 2020 - Taylor & Francis
Daily exposure to ultraviolet (UV) light induces inflammation and tumorigenesis in the skin.
Silibinin and ellagic acid are natural products that exhibit anti-inflammatory and anti …