The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …

Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and
describes its influence and related mechanisms on the biological behavior of pancreatic …

In order to achieve targeted delivery of anticancer drugs, efficacy improvement, and side
effect reduction, various types of nanoparticles are employed. However, their therapeutic …

Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer related
death. The urgent need for effective therapies is highlighted by the lack of adequate …

Hemophagocytic lymphohistiocytosis (HLH) is a highly fatal condition with the positive
feedback loop between continued immune cell activation and cytokine storm as the core …

Pancreatic cancer (PCa) is one of the leading causes of morbidity worldwide, and
theranostic approaches are ventured. The vast stroma surrounding PCa cells has been …

The tumor microenvironment (TME), as an immunosuppressive milieu, has a critical role in
tumor progression and increases resistance to the conventional treatments. Among the …

Extracellular biophysical properties have particular implications for a wide spectrum of
cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene …

Hypoxia, as a typical factor in a tumor microenvironment, plays a vital role in tumor treatment
resistance, tumor invasion and migration. Hypoxia inducible factor (HIF), as the vital …

In the past decade, we have witnessed the revolution in cancer therapy, especially in the
rapid development of cancer immunotherapy. In particular, the introduction of nanomedicine …