The two most common HIV-associated renal diseases, HIV-associated nephropathy and HIV
immune-complex kidney disease, share the common pathologic finding of hyperplasia …

Background Recently there has been an increasing interest and appreciation for the gut as
both a viral reservoir as well as an important host-pathogen interface in human …

The ZVITAMBO trial recruited 14,110 mother–infant pairs to a randomized controlled trial of
vitamin A between 1997 and 2000, before the availability of antiretroviral therapy for HIV …

With effective antiretroviral therapy (ART), cardiovascular diseases (CVD) are emerging as a
major cause of morbidity and death in the aging HIV-infected population. To address …

Nef is an accessory protein expressed exclusively in primate lentiviruses. It is devoid of
enzymatic activities while interacting with several cell proteins as an adaptor/scaffold …

HIV-1 infection of the central nervous system causes HIV-associated neurocognitive
disorders, even in aviremic patients. Although astrocyte malfunction was associated to these …

HIV-1–associated nephropathy (HIVAN) is a severe complication of HIV-1 infection. To gain
insight into the pathogenesis of kidney disease in the setting of HIV, a transgenic (Tg) mouse …

Alterations of T-cell receptor signaling by human immunodeficiency virus type 1 (HIV-1) Nef
involve its association with a highly active subpopulation of p21-activated kinase 2 (PAK2) …

ABSTRACT CD4C/HIVnef transgenic (Tg) mice express Nef in CD4+ T cells and in the cells
of the macrophage/monocyte/dendritic lineage, and they develop an AIDS-like disease …

We previously reported that CD4C/human immunodeficiency virus (HIV) Nef transgenic (Tg)
mice, expressing Nef in CD4+ T cells and cells of the macrophage/dendritic cell (DC) …