Post-viral effects of COVID-19 in the olfactory system and their implications

MS Xydakis, MW Albers, EH Holbrook… - The Lancet …, 2021 - thelancet.com
Background The mechanisms by which any upper respiratory virus, including SARS-CoV-2,
impairs chemosensory function are not known. COVID-19 is frequently associated with …

Persistent brainstem dysfunction in long-COVID: a hypothesis

SJ Yong - ACS chemical neuroscience, 2021 - ACS Publications
Long-COVID is a postviral illness that can affect survivors of COVID-19, regardless of initial
disease severity or age. Symptoms of long-COVID include fatigue, dyspnea, gastrointestinal …

How COVID-19 affects the brain

M Boldrini, PD Canoll, RS Klein - JAMA psychiatry, 2021 - jamanetwork.com
COVID-19 has resulted in more than 120 million cases and 2.6 million deaths to date.
Respiratory and gastrointestinal symptoms are accompanied by short-and long-term …

COVID-19 neuropathology at columbia university irving medical center/New York presbyterian hospital

KT Thakur, EH Miller, MD Glendinning, O Al-Dalahmah… - Brain, 2021 - academic.oup.com
Many patients with SARS-CoV-2 infection develop neurological signs and symptoms;
although, to date, little evidence exists that primary infection of the brain is a significant …

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

CA Butler, AS Popescu, EJA Kitchener… - Journal of …, 2021 - Wiley Online Library
There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

SARS‐CoV‐2 and the brain: A review of the current knowledge on neuropathology in COVID‐19

A Maiese, AC Manetti, C Bosetti, F Del Duca… - Brain …, 2021 - Wiley Online Library
Abstract SARS‐CoV‐2 (severe acute respiratory syndrome coronavirus 2), the new
coronavirus responsible for the pandemic disease in the last year, is able to affect the central …

Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model

C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
Background Neurological symptoms such as cognitive decline and depression contribute
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …

[HTML][HTML] Neuropathology of COVID-19 (neuro-COVID): clinicopathological update

JJ Lou, M Movassaghi, D Gordy, MG Olson… - Free …, 2021 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health
crisis in the early 21 st century. Its causative agent, Severe Acute Respiratory Syndrome …

SARS-CoV-2 infection of microglia elicits proinflammatory activation and apoptotic cell death

GU Jeong, J Lyu, KD Kim, YC Chung… - Microbiology …, 2022 - Am Soc Microbiol
Accumulating evidence suggests that severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection causes various neurological symptoms in patients with coronavirus …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …