Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities
N Yin, X Li, X Zhang, S Xue, Y Cao… - … and Targeted Therapy, 2024 - nature.com
Immunotherapy represented by anti-PD-(L) 1 and anti-CTLA-4 inhibitors has revolutionized
cancer treatment, but challenges related to resistance and toxicity still remain. Due to the …
cancer treatment, but challenges related to resistance and toxicity still remain. Due to the …
[HTML][HTML] Therapeutic strategies targeting CD47-SIRPα signaling pathway in gastrointestinal cancers treatment
Z Che, W Wang, L Zhang, Z Lin - Journal of Pharmaceutical Analysis, 2024 - Elsevier
Gastrointestinal (GI) cancers are prevalent globally, with leading incidence and mortality
rates among malignant tumors. Despite notable advancements in surgical resection …
rates among malignant tumors. Despite notable advancements in surgical resection …
CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition
J Wang, N Xie, S Lu, B Xiao, Y Ou, Q Li… - Advanced Functional …, 2024 - Wiley Online Library
Intracerebral hemorrhage (ICH) presents a formidable challenge due to its high mortality
and disability rates, primarily attributed to cerebral hematoma formation and ensuing …
and disability rates, primarily attributed to cerebral hematoma formation and ensuing …
Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients
X Su, W Jin, L Liu, Z Zhu, C Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Primary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic
autoimmune liver disease characterized by inflammatory injury of small and medium-sized …
autoimmune liver disease characterized by inflammatory injury of small and medium-sized …
Bioactive Self‐Assembled Nanoregulator Enhances Hematoma Resolution and Inhibits Neuroinflammation in the Treatment of Intracerebral Hemorrhage
W Yu, C Che, Y Yang, Y Zhao, J Liu, A Chen… - Advanced …, 2025 - Wiley Online Library
Hematoma and secondary neuroinflammation continue to pose a significant challenge in the
clinical treatment of intracerebral hemorrhage (ICH). This study describes a nanoregulator …
clinical treatment of intracerebral hemorrhage (ICH). This study describes a nanoregulator …
[HTML][HTML] Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases
CD47 is an immune checkpoint widely regarded as a 'don't eat me'signal. CD47-based anti-
cancer therapy has received considerable attention, with a significant number of clinical …
cancer therapy has received considerable attention, with a significant number of clinical …