Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …

The endoplasmic reticulum (ER) is the site of membrane protein insertion, folding, and
assembly in eukaryotes. Over the past few years, a combination of genetic and biochemical …

Ribosome movement is not always smooth and is rather often impeded. For ribosome
pauses, fundamental issues remain to be addressed, including where ribosomes pause on …

Halophenolic disinfection byproducts (DBPs) are a class of emerging pollutants whose
adverse effects on human cells and the underlying molecular mechanisms still need further …

Approximately 25% of eukaryotic genes code for integral membrane proteins that are
assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein …

Tail-anchored (TA) proteins play essential roles in mammalian cells, and their accurate
localization is critical for proteostasis. Biophysical similarities lead to mistargeting of …

Cells tightly regulate mRNA processing, localization, and stability to ensure accurate gene
expression in diverse cellular states and conditions. Most of these regulatory steps have …

Stalled protein synthesis produces defective nascent chains that can harm cells. In
response, cells degrade these nascent chains via a process called ribosome-associated …

Misfolded and mistargeted proteins in the early secretory pathway present significant risks to
the cell. A diverse and integrated network of quality control pathways protects the cell from …

Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components
linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that …