Targeting G protein-coupled receptors in cancer therapy
SM Soond, AA Zamyatnin Jr - Advances in cancer research, 2020 - Elsevier
As basic research into GPCR signaling and its association with disease has come into
fruition, greater clarity has emerged with regards to how these receptors may be amenable …
fruition, greater clarity has emerged with regards to how these receptors may be amenable …
Downregulation of GRK5 hampers the migration of breast cancer cells
AK Sommer, M Falcenberg, B Ljepoja, T Fröhlich… - Scientific reports, 2019 - nature.com
Sunitinib is a multispecific kinase inhibitor and one of its targets is the kinase GRK5, which is
regulating a multitude of G protein-coupled receptors (GPCRs). In this study we demonstrate …
regulating a multitude of G protein-coupled receptors (GPCRs). In this study we demonstrate …
GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis
AS Pathania, X Ren, MY Mahdi, GM Shackleford… - Scientific Reports, 2019 - nature.com
G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator
of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas …
of G-protein coupled receptors. However, GRK2 also has other functions. Medulloblastomas …
G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel
J Lagman, P Sayegh, CS Lee, SM Sulon… - Molecular and Cellular …, 2019 - Springer
G protein-coupled receptor kinases (GRKs) phosphorylate the activated forms of G protein-
coupled receptors (GPCRs), leading to receptor desensitization and internalization. In …
coupled receptors (GPCRs), leading to receptor desensitization and internalization. In …
G‐Protein‐Coupled Receptor Kinase 2 Inhibition Induces Meiotic Arrest by Disturbing Ca2+ Release in Porcine Oocytes
JD Kim, SH Lee, XH Li, QY Lu, CL Zhan… - … in Domestic Animals, 2024 - Wiley Online Library
ABSTRACT G‐protein‐coupled receptor kinase 2 (GRK2) interacts with Gβγ and Gαq,
subunits of G‐protein alpha, to regulate cell signalling. The second messenger inositol …
subunits of G‐protein alpha, to regulate cell signalling. The second messenger inositol …
[HTML][HTML] G protein–coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress
SA Henry, S Crivello, TM Nguyen, M Cybulska… - Cell Stress and …, 2021 - Elsevier
Survival and adaptation to oxidative stress is important for many organisms, and these occur
through the activation of many different signaling pathways. In this report, we showed that …
through the activation of many different signaling pathways. In this report, we showed that …