According to the World Health Organization (WHO), cancer is the second-highest cause of
mortality in the world, and it kills nearly 9.6 million people annually. Besides the fatality of the …

Cholestasis is a common manifestation of decreased bile flow in various liver diseases. It
results in fibrosis and even cirrhosis without proper treatment. It is believed that a wide range …

Background & Aims The pathways regulating liver regeneration have been extensively
studied within the liver. However, the signaling contribution derived from the gut microbiota …

Cyclophosphamide (CP), a chemotherapeutic agent, is restricted due to its side effects,
especially hepatotoxicity. Ginseng has often been clinically used with CP in China, but …

The main purpose of this study was to investigate the improvement effect of Mesona
chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in …

Background Rheum palmatum, R. tanguticum, and R. officinale, integral species of the
genus Rheum, are widely used across global temperate and subtropical regions. These …

Highlights•Cholestatic liver diseases and bile acid homeostasis are closely
connected.•Numerous signaling molecules are associated with bile acid transporters, tight …

Liver diseases have been a common challenge for people all over the world, which
threatens the quality of life and safety of hundreds of millions of patients. China is a major …

Background and purpose: Silymarin, a standardized extract of the milk thistle seeds, has
been widely used to treat chronic hepatitis, cirrhosis, and other types of toxic liver damage …

Ethnopharmacological relevance Gentiopicroside (GPS), one of iridoid glucoside
representatives, is the most potential active component in Gentiana rigescens Franch. ex …