Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Microtubules are dynamic cytoskeletal filaments composed of αβ-tubulin heterodimers.
Historically, the dynamics of single tubulin interactions at the growing microtubule tip have …

Microtubules are born and reborn continuously, even during quiescence. These polymers
are nucleated from templates, namely γ-tubulin ring complexes (γ-TuRCs) and severed …

Acetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known
posttranslational modification in the microtubule lumen. It marks stable microtubules and is …

Recent developments in image processing have greatly advanced our understanding of
biomolecular processes in vitro and in vivo. In particular, using Gaussian models to fit the …

Background The dynamic properties of microtubules depend on complex nanoscale
structural rearrangements in their end regions. Members of the EB1 and XMAP215 protein …

Microtubule assembly is vital for many fundamental cellular processes. Current models for
microtubule assembly kinetics assume that the subunit dissociation rate from a microtubule …

Tubulin polymers, microtubules, can switch abruptly from the assembly to shortening. These
infrequent transitions, termed" catastrophes", affect numerous cellular processes but the …

Microtubules are key players in cellular self-organization, acting as structural scaffolds,
cellular highways, force generators and signalling platforms. Microtubules are polar …

Microtubules are structural polymers inside of cells that are subject to posttranslational
modifications. These posttranslational modifications create functionally distinct subsets of …