COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges

K Dhama, M Dhawan, R Tiwari, TB Emran… - Human vaccines & …, 2022 - Taylor & Francis
Multiple vaccines have recently been developed, and almost all the countries are presently
vaccinating their population to tackle the COVID-19 pandemic. Most of the COVID-19 …

Biological nanoparticles in vaccine development

SM Curley, D Putnam - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Vaccines represent one of the most successful public health initiatives worldwide. However,
despite the vast number of highly effective vaccines, some infectious diseases still do not …

An intranasal OMV-based vaccine induces high mucosal and systemic protecting immunity against a SARS-CoV-2 infection

PA van der Ley, A Zariri, E van Riet… - Frontiers in …, 2021 - frontiersin.org
The development of more effective, accessible, and easy to administer COVID-19 vaccines
next to the currently marketed mRNA, viral vector, and whole inactivated virus vaccines is …

Production and purification of bacterial membrane vesicles for biotechnology applications: Challenges and opportunities

KF Castillo‐Romero, A Santacruz… - …, 2023 - Wiley Online Library
Bacterial membrane vesicles (BMVs) are bi‐layered nanostructures derived from Gram‐
negative and Gram‐positive bacteria. Among other pathophysiological roles, BMVs are …

Recent advances in various bio-applications of bacteria-derived outer membrane vesicles

L Sadeghi, E Mohit, S Moallemi, FM Ahmadi… - Microbial …, 2023 - Elsevier
Outer membrane vesicles (OMVs) are spherical nanoparticles released from bacteria. OMVs
were originally classified into native 'nOMVs'(produced naturally from budding of bacteria) …

Pentavalent outer membrane vesicles immunized mice sera confers passive protection against five prevalent pathotypes of diarrhoeagenic Escherichia coli in …

S Banerjee, P Halder, S Das, S Maiti, U Bhaumik… - Immunology …, 2023 - Elsevier
Diarrhoeagenic Escherichia coli (DEC) pathotypes are one of the major causative agents of
diarrhoea induced childhood morbidity and mortality in developing countries. Licensed …

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)

DJ Vance, S Basir, CL Piazza, GG Willsey… - Infection and …, 2024 - Am Soc Microbiol
Camelid-derived, single-domain antibodies (VHHs) have proven to be extremely powerful
tools in defining the antigenic landscape of immunologically heterogeneous surface …

Recombinant ClearColi™-derived outer membrane vesicles as an effective carrier for development of neoepitope-based vaccine candidate against colon carcinoma

E Sharif, N Nezafat, E Mohit - International Immunopharmacology, 2024 - Elsevier
Background Colorectal carcinoma (CRC) is the third most common cancer worldwide, with
high clonal heterogeneity due to somatic mutations. Poly neoepitope vaccines can inhibit …

Outer membrane vesicles as a platform for the discovery of antibodies to bacterial pathogens

EK Lei, A Azmat, KA Henry, G Hussack - Applied Microbiology and …, 2024 - Springer
Bacterial outer membrane vesicles (OMVs) are nanosized spheroidal particles shed by gram-
negative bacteria that contain biomolecules derived from the periplasmic space, the …

Evaluation of Outer Surface Protein Vaccine Candidates of Borrelia burgdorferi for Lyme Disease

I Liekniņa, A Kozlova, M Šaško, I Akopjana… - Microbiology …, 2023 - mdpi.com
Lyme disease affects several hundred thousand people worldwide annually, yet there is no
registered vaccine for the disease available for human use. The disease is caused by …