The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

KA Michaelis, MA Norgard, X Zhu… - Nature …, 2019 - nature.com
A priority in cancer research is to innovate therapies that are not only effective against tumor
progression but also address comorbidities such as cachexia that limit quality and quantity …

Brain control of appetite during sickness

G Aviello, C Cristiano, SM Luckman… - British journal of …, 2021 - Wiley Online Library
Given the high‐energy requirements to sustain immune responses and healing processes, it
is intriguing that lack of appetite (ie, anorexia) is a cardinal feature of sickness behaviour …

[PDF][PDF] Thermoregulation, energy balance, regulatory peptides: recent developments

M Szekely, E Petervari, M Balasko - Front Biosci (Schol Ed), 2010 - article.imrpress.com
[Frontiers in Bioscience S2, 1009-1046, June 1, 2010] 1009 Thermoregulation, energy balance,
regulatory peptides: recent develop Page 1 [Frontiers in Bioscience S2, 1009-1046, June 1 …

Peripheral lipopolysaccharide administration transiently affects expression of brain-derived neurotrophic factor, corticotropin and proopiomelanocortin in mouse brain

S Schnydrig, L Korner, S Landweer, B Ernst… - Neuroscience …, 2007 - Elsevier
Peripheral inflammation induced by intraperitoneal (ip) injection of Lipopolysaccharide
(LPS) is known to cause functional impairments in the brain affecting memory and learning …

Neurobiology of inflammation-associated anorexia

L Gautron, S Layé - Frontiers in neuroscience, 2010 - frontiersin.org
Compelling data demonstrate that inflammation-associated anorexia directly results from the
action of pro-inflammatory factors, primarily cytokines and prostaglandins E2, on the nervous …

Implication of neuropeptide-Y Y2 receptors in the effects of immune stress on emotional, locomotor and social behavior of mice

E Painsipp, H Herzog, P Holzer - Neuropharmacology, 2008 - Elsevier
Neuropeptide Y (NPY) is involved in the regulation of emotional behavior, and there is
indirect evidence for a role of NPY in the cerebral responses to peripheral immune …

Variation of lipopolysaccharide-induced acute lung injury in eight strains of mice

AS Alm, K Li, H Chen, D Wang, R Andersson… - Respiratory physiology & …, 2010 - Elsevier
Clinical and experimental evidence suggests that genetic variations may play an important
role in the development of acute lung injury (ALI). Lipopolysaccharide (LPS)-induced ALI …

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

X Du, TY Pang, C Mo, T Renoir, DJ Wright… - Experimental …, 2015 - Elsevier
Huntington's disease (HD) is an autosomal dominant, neurodegenerative disease caused
by a CAG tandem repeat mutation encoding a polyglutamine tract expansion in the …

Sustained Inflammation Induced by LPS Leads to Tolerable Anorexia and Fat Loss via Tlr4 in Mice

Y Yang, W Zhong, Y Zhang, Y Cheng… - Journal of …, 2022 - Taylor & Francis
Background Sustained inflammation is implicated in a variety of pathological conditions like
infection, obesity and type 2 diabetes. Lipid metabolism is crucial to support immune …

Influence of peripheral lipopolysaccharide (LPS) on feed intake, body temperature and hypothalamic expression of neuropeptides involved in appetite regulation in …

M Yousefi, H Jonaidi, B Sadeghi - British Poultry Science, 2021 - Taylor & Francis
This study examined the expression of genes related to appetite-regulating neuropeptides in
the hypothalamus of broiler and layer chicks (Gallus gallus) after intraperitoneal (IP) …