Neuronal events are regulated by the integration of several complex signaling networks in
which G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are …

The heteroreceptor complexes present a novel biological principle for signal integration.
These complexes and their allosteric receptor–receptor interactions are bidirectional and …

Depression and anxiety are major global health burdens. Although SSRIs targeting the
serotonergic system are prescribed over 200 million times annually, they have variable …

Abstract Cannabidiol (CBD), a phytocannabinoid, has emerged as a promising candidate for
addressing a wide array of symptoms. It has the ability to bind multiple proteins and …

Background Use of antidepressant medications has been linked to detrimental impacts on
bone mineral density and osteoporosis; however, the cellular basis behind these …

Fluoxetine is one of the most commonly used antidepressants. Fluoxetine could prevent the
mesenchymal stem cell differentiation in lung fetus of rat. Moreover, the mesenchymal stem …

The lack of understanding in the molecular and cellular mechanisms of Alzheimer's disease
(AD) has hindered efforts towards finding treatments that effectively modify disease …

Crosstalk between receptors allows for the integration of diverse and complex signalling
pathways. Transactivation is a form of crosstalk between G-protein coupled receptors …