Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

A fundamental feature of both early nervous system development and axon regeneration is
the guidance of axonal projections to their targets in order to assemble neural circuits that …

Reconstructing functional neuronal circuits is one major challenge of central nervous system
repair. Through activation of pro-growth signaling pathways, some neurons achieve long …

In the injured adult central nervous system (CNS), activation of pro-growth molecular
pathways in neurons leads to long-distance regeneration. However, most regenerative …

Optic nerve injury is a leading cause of irreversible visual impairment worldwide and can
even cause blindness. Excessive activation of astrocytes has negative effects on the repair …

Multiple cellular components are involved in the complex pathological process following
central nervous system (CNS) injury, including neurons, glial cells and endothelial cells …

Background Optic neuropathy is a major cause of irreversible blindness, yet the molecular
determinants that contribute to neuronal demise have not been fully elucidated. Several …

Prostate cancer (PCa) remains the second-leading cause of cancer-related deaths in
American men with an estimated mortality of more than 26,000 in 2016 alone. Aggressive …

Nogo-A is a well-known myelin-enriched inhibitory protein for axonal growth and
regeneration in the central nervous system (CNS). Besides oligodendrocytes, our previous …

Nogo-A protein consists of two main extracellular domains: Nogo-66 (rat amino acid [aa]
1019–1083) and Nogo-A-Δ20 (extracellular, active 180 amino acid Nogo-A region), which …