Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Inducing immune tolerance with dendritic cell-targeting nanomedicines
A Cifuentes-Rius, A Desai, D Yuen… - Nature …, 2021 - nature.com
Induced tolerogenic dendritic cells are a powerful immunotherapy for autoimmune disease
that have shown promise in laboratory models of disease and early clinical trials. In contrast …
that have shown promise in laboratory models of disease and early clinical trials. In contrast …
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
Biomaterials Facilitating Dendritic Cell‐Mediated Cancer Immunotherapy
Dendritic cell (DC)‐based cancer immunotherapy has exhibited remarkable clinical
prospects because DCs play a central role in initiating and regulating adaptive immune …
prospects because DCs play a central role in initiating and regulating adaptive immune …
[HTML][HTML] Engineering poly-and micelleplexes for nucleic acid delivery–A reflection on their endosomal escape
B Winkeljann, DC Keul, OM Merkel - Journal of Controlled Release, 2023 - Elsevier
For the longest time, the field of nucleic acid delivery has remained skeptical whether or not
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …
polycationic drug carrier systems would ever make it into clinical practice. Yet, with the …
Targeting tumor antigens to dendritic cells using particulate carriers
Dendritic cells play a central role in antigen presentation and generation of cytotoxic T
lymphocyte (CTL) response required for anticancer vaccination. The review focuses on use …
lymphocyte (CTL) response required for anticancer vaccination. The review focuses on use …
Mannosylation of LNP results in improved potency for self-amplifying RNA (SAM) vaccines
R Goswami, D Chatzikleanthous, G Lou… - ACS infectious …, 2019 - ACS Publications
Mannosylation of Lipid Nanoparticles (LNP) can potentially enhance uptake by Antigen
Presenting Cells, which are highly abundant in dermal tissues, to improve the potency of …
Presenting Cells, which are highly abundant in dermal tissues, to improve the potency of …
Liposomal vaccine formulations as prophylactic agents: design considerations for modern vaccines
LO De Serrano, DJ Burkhart - Journal of nanobiotechnology, 2017 - Springer
Vaccinology is one of the most important cornerstones in modern medicine, providing better
quality of life. The human immune system is composed of innate and adaptive immune …
quality of life. The human immune system is composed of innate and adaptive immune …
Liposome-based delivery system for vaccine candidates: constructing an effective formulation
The discovery of liposomes in 1965 by Bangham and coworkers changed the prospects of
drug delivery systems. Since then, the application of liposomes as vaccine delivery systems …
drug delivery systems. Since then, the application of liposomes as vaccine delivery systems …
Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses
SB Rizwan, WT McBurney, K Young, T Hanley… - Journal of Controlled …, 2013 - Elsevier
New generation vaccines increasingly utilize highly purified peptides and proteins as the
target antigen, however these are often poorly immunogenic. One of the most promising …
target antigen, however these are often poorly immunogenic. One of the most promising …