Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Death receptors are members of the tumor necrosis factor receptor superfamily
characterized by a cytoplasmic region known as the “death domain” that enables the …

The inactivation of programmed cell death has profound effects not only on the development
but also on the overall integrity of multicellular organisms. Beside developmental …

Virtually all of the measurable cell-mediated cytotoxicity delivered by cytotoxic T
lymphocytes and natural killer cells comes from either the granule exocytosis pathway or the …

The hepatocyte is especially vulnerable to injury due to its central role in xenobiotic
metabolism including drugs and alcohol, participation in lipid and fatty acid metabolism, its …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a
potential anticancer agent. However, considerable numbers of cancer cells, especially some …

Many of today's medical illnesses can be attributed directly or indirectly to problems with
apoptosis—a programmed cell-suicide mechanism. Disorders in which defective regulation …

A novel anti-human DR5 monoclonal antibody, TRA-8, induces apoptosis of most tumor
necrosis factor-related apoptosis-inducing ligand (TRAIL)-sensitive tumor cells both in vitro …

The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely
unknown, although the mechanism of TNF-induced apoptosis has been studied extensively …