Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Old individuals are more susceptible to various infections due to immunological changes
that occur during the aging process. These changes named collectively as …

Senescent cells accumulate in human tissues during ageing and contribute to age-related
pathologies. The mechanisms responsible for their accumulation are unclear. Here we show …

Over the past years, the phenotypic and functional boundaries distinguishing the main cell
subsets of the immune system have become increasingly blurred. In this respect, CD56 (also …

Innate and adaptive immune responses decline with age, leading to greater susceptibility to
infectious diseases and reduced responses to vaccines. Diseases are more severe in old …

People aged 60 and older represent over 11% of the world population and it is expected to
rise 22% by 2050. Population aging is associated to an increased frequency of age-related …

Chronic low-grade inflammation has a key role in the aging process, a state called
inflammaging. It is known that the chronic inflammatory condition generates counteracting …