Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

The devastating infections that fungal pathogens cause in humans are underappreciated
relative to viral, bacterial and parasitic diseases. In recent years, the contributions to …

Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

Iron is an essential micronutrient for virtually all eukaryotic organisms and plays a central
role during microbial infections. Invasive fungal diseases are associated with strikingly high …

Iron is a key transition metal required by most microorganisms and is prominently utilised in
the transfer of electrons during metabolic reactions. The acquisition of iron is essential and …

Extracellular vesicles (EVs) are membranous vesicular organelles that perform a variety of
biological functions including cell communication across different biological kingdoms. EVs …

Members of Cryptococcus gattii/neoformans species complex are the etiological agents of
the potentially fatal human fungal infection cryptococcosis. C. gattii and its sister species …

Iron acquisition is challenging in most environments. As an alternative to elemental iron,
organisms can take up iron-protoporphyrin IX, or heme. Heme can be found in decaying …

Highlights•Heme can be used as iron source in saprophytic and parasitic fungi.•Parasitic
fungi can utilize heme from blood hemoglobin.•C. albicans secretes hemophores of the …