Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Glaucoma is a degenerative disease of the eye. Both the anterior and posterior segments of
the eye are affected, extensive damage being detectable in the trabecular meshwork and …

Autophagy plays an adaptive role in cell survival, development, differentiation and
intracellular homeostasis. Autophagy is recognized as a'self-cannibalizing'process that is …

Activation of autophagy is one of the responses elicited by high intraocular pressure (IOP)
and mechanical stretch in trabecular meshwork (TM) cells. However, the mechanosensor …

The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the
anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous …

The aqueous humor (AH) outflow pathways definition is still matter of intense debate. To
date, the differentiation between conventional (trabecular meshwork) and unconventional …

The trabecular meshwork (TM) plays an important role in high‐tension glaucomas. Indeed,
the TM is a true organ, through which the aqueous humor flows from the anterior chamber to …

During the last few years, the autophagy lysosomal system is emerging as a central cellular
pathway with roles in survival, acting as a housekeeper and stress response mechanism …

The ability to derive retinal ganglion cells (RGCs) from human pluripotent stem cells
(hPSCs) has led to numerous advances in the field of retinal research, with great potential …

Primary open angle glaucoma (POAG) is a degenerative disease commonly associated with
aging and elevated intraocular pressure (IOP). Higher resistance to aqueous humor (AH) …