Instability of the mitochondrial genome (mtDNA) is a general problem from yeasts to
humans. However, its genetic control is not well documented except in the yeast …

Fifty years ago it was reported that baker's yeast, Saccharomyces cerevisiae, can form
“petite colonie” mutants when treated with the DNA-targeting drug acriflavin. To mark the …

Survival of bloodstream form Trypanosoma brucei, the agent of African sleeping sickness,
normally requires mitochondrial gene expression, despite the absence of oxidative …

The yeast Saccharomyces cerevisiae reproduces by asymmetric cell division, or budding. In
each cell division, the daughter cell is usually smaller and younger than the mother cell, as …

The mitochondrial F0F1 ATP synthase is an essential multi-subunit protein complex in the
vast majority of eukaryotes but little is known about its composition and role in Trypanosoma …

The mitochondrial ATP synthase is a multimeric enzyme complex with an overall molecular
weight of about 600,000 Da. The ATP synthase is a molecular motor composed of two …

Publisher Summary This chapter briefly reviews some recent advances in the areas of the
subunit structure and the different functions of the ATP synthase, but focuses mainly on the …

Transcriptional rewiring generates phenotypic novelty, acting as an important mechanism
contributing to evolutionary development, speciation, and adaptation in all organisms. The …

As a legacy of their endosymbiotic eubacterial origin, mitochondria possess a residual
genome, encoding only a few proteins and dependent on a variety of factors encoded by the …

The biogenesis of mitochondria requires the integration of many proteins into the inner
membrane from the matrix side. The inner membrane protein Oxa1 plays an important role …