JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

A deadly embrace: Hemagglutination mediated by SARS-CoV-2 spike protein at its 22 N-glycosylation sites, red blood cell surface sialoglycoproteins, and antibody

DE Scheim - International journal of molecular sciences, 2022 - mdpi.com
Rouleaux (stacked clumps) of red blood cells (RBCs) observed in the blood of COVID-19
patients in three studies call attention to the properties of several enveloped virus strains …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …

Mast cell and eosinophil activation are associated with COVID-19 and TLR-mediated viral inflammation: implications for an anti-Siglec-8 antibody

S Gebremeskel, J Schanin, KM Coyle… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a
global health crisis. Immune cell activation via pattern recognition receptors has been …

The enigma of endothelium in COVID-19

S Kaur, DM Tripathi, A Yadav - Frontiers in Physiology, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome–
related coronavirus-2 (SARS-CoV-2) has affected millions of people globally. Clinically, it …

Computational bioprospecting guggulsterone against ADP ribose phosphatase of SARS-CoV-2

M Kciuk, S Mujwar, I Rani, K Munjal, A Gielecińska… - Molecules, 2022 - mdpi.com
Coronavirus Disease-2019 (COVID-19) is a highly contagious disease caused by Severe
Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization …

Retinal microvascular signs in COVID-19

R Sim, G Cheung, D Ting, E Wong, TY Wong… - British Journal of …, 2022 - bjo.bmj.com
Background/aims To explore if retinal findings are associated with COVID-19 infection.
Methods In this prospective cross-sectional study, we recruited participants positive for …

In silico bioprospecting of taraxerol as a main protease inhibitor of SARS-CoV-2 to develop therapy against COVID-19

S Mujwar, RK Harwansh - Structural Chemistry, 2022 - Springer
COVID-19 was caused by a novel coronavirus known as SARS-CoV-2. The COVID-19
disease outbreak has been avowed as a global pandemic by the World Health Organization …

The role of the coagulation system in peripheral arterial disease: interactions with the Arterial Wall and its vascular microenvironment and implications for rational …

G Miceli, MG Basso, G Rizzo, C Pintus… - International Journal of …, 2022 - mdpi.com
Peripheral artery disease (PAD) is a clinical manifestation of atherosclerotic disease with a
large-scale impact on the economy and global health. Despite the role played by platelets in …

Janus kinase signaling pathway and its role in COVID-19 inflammatory, vascular, and thrombotic manifestations

JD Ravid, O Leiva, VC Chitalia - Cells, 2022 - mdpi.com
Acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection continues to be a
worldwide public health crisis. Among the several severe manifestations of this disease …