Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

As synthetic biology permeates society, the signal processing circuits in engineered living
systems must be customized to meet practical demands. Towards this mission, novel …

In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …

The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

Massively parallel genetic screens have been used to map sequence-to-function
relationships for a variety of genetic elements. However, because these approaches only …

Engineered signaling networks can impart cells with new functionalities useful for directing
differentiation and actuating cellular therapies. For such applications, the engineered …

Nowadays, cancers still represent a significant health burden, accounting for around 10
million deaths per year, due to ageing populations and inefficient treatments for some …

RNAs and their encoded proteins intricately regulate diverse cell types and states within the
human body. Dysregulated RNA expressions or mutations can lead to various diseased cell …

Nowadays, most organizations face the challenge of having to track the latest technological
developments so as to discover new technology opportunities and to identify threats in their …

Inteins are proteins found in nature that execute protein splicing. Among them, split inteins
stand out for their versatility and adaptability, presenting creative solutions for addressing …