Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

The role of the mitochondria in disease, general health and aging has drawn much attention
over the years. Several attempts have been made to describe how the numbers of …

Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate …

Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited
organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It …

Mitochondria are key organelles in eukaryotic cells principally responsible for multiple
cellular functions. In addition to a plethora of somatic mutations as well as polymorphic …

Lung cancer is one of the leading causes of cancer-related death in developed countries.
Despite decades of intensive efforts to comate this malignant disease, the prognosis of lung …

Mitochondria are the critical organelles involved in various cellular functions. Mitochondrial
biogenesis is activated by multiple cellular mechanisms which require a synchronous …

Mitochondria control essential cellular activities including generation of ATP via oxidative
phosphorylation. Mitochondrial DNA (mtDNA) mutations in the regulatory D-loop region and …

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high
mortality in industrialized countries: cardiovascular disease and diabetes. An important …