The evolving nature of biocatalysis in pharmaceutical research and development
Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …
Biocatalytic reductive aminations with NAD (P) H-dependent enzymes: enzyme discovery, engineering and synthetic applications
Chiral amines are pivotal building blocks for the pharmaceutical industry. Asymmetric
reductive amination is one of the most efficient and atom economic methodologies for the …
reductive amination is one of the most efficient and atom economic methodologies for the …
Emerging technologies for biocatalysis in the pharmaceutical industry
Biocatalysis is a key technology in the pharmaceutical industry as it can provide efficient and
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …
sustainable catalytic routes toward active pharmaceutical ingredients (APIs). The …
Reductive aminations by imine reductases: from milligrams to tons
The synthesis of secondary and tertiary amines through the reductive amination of carbonyl
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …
compounds is one of the most significant reactions in synthetic chemistry. Asymmetric …
Assembly of (hetero) aryl thioethers via simple nucleophilic aromatic substitution and Cu-catalyzed coupling reactions with (hetero) aryl chlorides and bromides under …
W Liu, X Jin, D Ma - Green Chemistry, 2023 - pubs.rsc.org
The requirement of higher reaction temperatures for an SNAr reaction between thiols and
less reactive electron-poor aryl halides described in earlier reports has triggered intensive …
less reactive electron-poor aryl halides described in earlier reports has triggered intensive …
Imine Reductases and Reductive Aminases in Organic Synthesis
GA Aleku - ACS Catalysis, 2024 - ACS Publications
Imine reductases (IREDs) and reductive aminases (RedAms) are NADPH-dependent
oxidoreductases catalyzing C–N redox reactions. These include the enantioselective …
oxidoreductases catalyzing C–N redox reactions. These include the enantioselective …
Catalyzing the future: Recent advances in chemical synthesis using enzymes
JC Reisenbauer, KM Sicinski, FH Arnold - Current opinion in chemical …, 2024 - Elsevier
Highlights•Engineered biocatalysts that access pharmaceutical products through more
sustainable synthetic routes.•Novel biocatalysts that construct enantiomerically enriched …
sustainable synthetic routes.•Novel biocatalysts that construct enantiomerically enriched …
Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor
Biocatalytic reductive amination reactions with reductive aminases (RedAms) are emerging
transformations with a high potential value for pharmaceutical synthesis. Here, we report the …
transformations with a high potential value for pharmaceutical synthesis. Here, we report the …
Asymmetric Reductive Amination in Organocatalysis and Biocatalysis
T Li, Q Zhou, F Meng, W Cui, Q Li… - European Journal of …, 2023 - Wiley Online Library
This review summarizes the recent progress of organocatalytic and biocatalytic asymmetric
reductive amination (ARA), a challenging but important topic for drug discovery and the …
reductive amination (ARA), a challenging but important topic for drug discovery and the …
Highlights of the recent patent literature─ focus on biocatalysis innovation
DL Hughes - Organic Process Research & Development, 2022 - ACS Publications
This review surveys recent advances in biocatalysis, with a primary focus on contributions
from the patent literature since 2018, including reductive aminations, nitro reductions …
from the patent literature since 2018, including reductive aminations, nitro reductions …