Neurons, perhaps more than any other cell type, depend on mitochondrial trafficking for their
survival. Recent studies have elucidated a motor/adaptor complex on the mitochondrial …

The past decade has seen a remarkable explosion in our knowledge of the size and
diversity of the myosin superfamily. Since these actin-based motors are candidates to …

The cargo that the molecular motor kinesin moves along microtubules has been elusive. We
searched for binding partners of the COOH terminus of kinesin light chain, which contains …

Multicellular organisms clearly require mechanisms for intercellular communication and,
perhaps even more basically, for intercellular cohesion. The most primitive sponges and …

MAP2 and tau exhibit microtubule-stabilizing activities that are implicated in the
development and maintenance of neuronal axons and dendrites. The proteins share a …

Filopodia are thin cellular protrusions that are important in cell motility and neuronal growth
cone guidance. The actin filaments that make up the core of a filopodium undergo …

In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is
required for the faithful transmission of the genome to the two daughter cells during division …

The asymmetric localization of messenger RNA (mRNA) and protein determinants plays an
important role in the establishment of complex body plans. In Drosophila oocytes, the …

Kinesins and dyneins play important roles during cell division. Using RNA interference
(RNAi) to deplete individual (or combinations of) motors followed by immunofluorescence …

During anaphase identical sister chromatids separate and move towards opposite poles of
the mitotic spindle,. In the spindle, kinetochore microtubules have their plus ends embedded …