Several lipoxygenase enzymes and cyclooxygenase-2 stereoselectively convert the
polyunsaturated fatty acids arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid …

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …

Neutrophils, the most abundant white blood cell in human blood, express receptors that
recognize damage/microbial associated pattern molecules of importance for cell recruitment …

Oxylipins derived mainly from C20-and C22-polyunsaturated fatty acids (PUFAs), termed
lipid mediators (LMs), are essential signalling messengers involved in human physiological …

The methyl ester of resolvin D5n-3 DPA, a lipid mediator biosynthesized from the omega-3
fatty acid n-3 docosapentaenoic acid, was stereoselectively prepared in 8% yield over 12 …

Herein, we report the stereoselective and convergent synthesis of resolvin E4, a newly
identified specialized pro-resolving mediator. This synthesis proves the absolute …

Activation as well as recruitment of neutrophils, the most abundant leukocyte in human
blood, to sites of infection/inflammation largely rely on surface-exposed chemoattractant …

The resolution of inflammation is a biosynthetically active process controlled by the interplay
between oxygenated polyunsaturated mediators and G-protein coupled receptor-signaling …

Specialized pro-resolving mediators (SPMs) are multifunctional lipid mediators that
participate in the resolution of inflammation. We have recently described that oral epithelial …

Two stereocontrolled, efficient, and modular syntheses of eicosanoid lipoxin B4 (LXB4) are
reported. One features a stereoselective reduction followed by an asymmetric epoxidation …