Epidemiological studies have shown a positive relationship between dietary fat intake and
obesity. Since rats and mice show a similar relationship, they are considered an appropriate …

Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti‐related peptide
(AgRP) govern a critical aspect of survival: the drive to eat. Equally important to survival is …

The fat-derived hormone leptin regulates energy balance in part by modulating the activity of
neuropeptide Y and proopiomelanocortin neurons in the hypothalamic arcuate nucleus. To …

Leptin resistance in diet-induced obese (DIO) mice is characterized by elevated serum leptin
and a decreased response to exogenous leptin and is caused by unknown defects in the …

Despite high leptin levels, most obese humans and rodents lack responsiveness to its
appetite-suppressing effects. We demonstrate that leptin modulates NPY/AgRP and α-MSH …

Mechanism exploitation of energy homeostasis is urgently required because of the
worldwide prevailing of obesity-related metabolic disorders in human being. Although it is …

Obesity-related hypogonadotropic hypogonadism is a well-characterized condition in men
(termed male obesity-related secondary hypogonadism; MOSH); however, an equivalent …

Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its
effects on reducing energy expenditure. However, the pathways involved and the regulatory …

Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in …

Appetite regulation is part of a feedback system that controls the energy balance, involving a
complex interplay of hunger and satiety signals, produced in the hypothalamus as well as in …