Advances in animal models of prenatal opioid exposure

JR Ferrante, JA Blendy - Trends in Neurosciences, 2024 - cell.com
Neonatal opioid withdrawal syndrome (NOWS) is a growing public health concern. The
complexity of in utero opioid exposure in clinical studies makes it difficult to investigate …

Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice

BL Smith, A Hassler, KR Lloyd, TM Reyes - Neurotoxicology, 2023 - Elsevier
Within the national opioid epidemic, there has been an increase in the number of infants
exposed to opioids in utero. Additionally, opioid agonist medications are the standard of …

Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence

A Flores, NM Nguyen, M Devanaboyina… - Journal of Neuroimmune …, 2024 - Springer
The opioid epidemic has received considerable attention, but the impact on perinatal opioid-
exposed (POE) offspring remains underexplored. This study addresses the emerging public …

Early life cancer and chemotherapy lead to cognitive deficits related to alterations in microglial-associated gene expression in prefrontal cortex

CJ Laaker, C Cantelon, AB Davis, KR Lloyd… - Brain, Behavior, and …, 2023 - Elsevier
Children that survive leukemia are at an increased risk for cognitive difficulties. A better
understanding of the neurobiological changes in response to early life chemotherapy will …

Sex differences in neonatal outcomes following prenatal opioid exposure

NK Madurai, LL Jantzie, E Yen - Frontiers in Pediatrics, 2024 - frontiersin.org
The impact of the opioid epidemic on pregnant people and children is a growing public
health crisis. Understanding how opioids affect the developing brain during pregnancy and …

Chronic morphine exposure and maternal separation induce impairments in cognition and locomotor activity of male adolescent rats

M Fadaei‐kenarsary, K Esmaeilpour… - International Journal …, 2023 - Wiley Online Library
Maternal morphine exposure reduces motivation for basic cognitive tasks, followed by
executive function deficits in attention and accuracy. It also induces depression‐like …

Repeated activation of pyramidal neurons in the prefrontal cortex alters microglial phenotype in male mice

JL Bollinger, MJ Horchar, ES Wohleb - Journal of Pharmacology and …, 2024 - ASPET
Aberrant neuronal activity in the cortex alters microglia phenotype and function in several
contexts, including chronic psychologic stress and neurodegenerative disease. Recent …

Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

AD Dunn, SA Robinson, C Nwokafor, M Estill… - Frontiers in Behavioral …, 2023 - frontiersin.org
Introduction Infants exposed to opioids in utero are at high risk of exhibiting Neonatal Opioid
Withdrawal Syndrome (NOWS), a combination of somatic withdrawal symptoms including …

[HTML][HTML] Effects of prenatal exposure to methadone or buprenorphine and maternal separation on anxiety-like behavior in rats

H Nyberg, IL Bogen, E Nygaard… - Drug and Alcohol …, 2024 - Elsevier
Background The use of medications for opioid use disorder such as methadone or
buprenorphine is increasing among pregnant women. However, long-term effects of this …

[HTML][HTML] Increased LPS-Induced Fever and Sickness Behavior in Adult Male and Female Rats Perinatally Exposed to Morphine

HJ Harder, MG Gomez, CT Searles, ME Vogt… - bioRxiv, 2023 - ncbi.nlm.nih.gov
As a result of the current opioid crisis, the rate of children born exposed to opioids has
skyrocketed. Later in life, these children have an increased risk for hospitalization and …