Neuroblastoma (NB) is a pediatric tumor of embryonic origin. About 1–2% of all NBs are
familial cases, and genetic predisposition is suspected for the remaining cases. During the …

Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …

Background Neuroblastoma (NB) is the most common solid extracranial paediatric tumour.
Genome-wide association studies have driven the discovery of common risk variants, but no …

Background FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and
acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in …

Noncoding cis-regulatory variants have gained interest as cancer drivers, yet progress in
understanding their significance is hindered by the numerous challenges and limitations of …

A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …

Neuroblastoma (NB) is the most common extracranial tumor in children. YTHDC1, a member
of RNA methylation modification binding proteins, plays critical roles in tumor occurrence …

Background Emerging evidence suggests that non-coding somatic single nucleotide
variants (SNVs) in cis-regulatory elements (CREs) contribute to cancer by disrupting gene …

Neuroblastoma is a primary malignancy mainly occurring in children. We have reported that
polymorphisms of several N6-methyladenosine (m6A) RNA modification-related genes …

More than 300 membranes make up the SLC family of transporters, utilizing an ion gradient
or electrochemical potential difference to move their substrates across biological …