The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

Hydroxyurea (HU) is mostly referred to as an inhibitor of ribonucleotide reductase (RNR)
and as the agent that is commonly used to arrest cells in the S-phase of the cycle by …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Genome replication involves dealing with obstacles that can result from DNA damage but
also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA …

Abstract The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1
DNA helicase family, which is conserved from bacteria to humans. Here we show that …

Genome maintenance is a constant concern for cells, and a coordinated response to DNA
damage is required to maintain cellular viability and prevent disease. The ataxia …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

Summary G-quadruplex (G4) DNA structures are extremely stable four-stranded secondary
structures held together by noncanonical GG base pairs. Genome-wide chromatin …

Topoisomerase I (Top1) is a key enzyme in functioning at the interface between DNA
replication, transcription and mRNA maturation. Here, we show that Top1 suppresses …