Underlying the development of malaria parasites within erythrocytes and the resulting
pathogenicity is a hardwired program that secures proper timing of gene transcription and …

Malaria parasites can readily sense and adapt to environmental changes, thus making the
control and eradication of this disease difficult. Molecular studies have unraveled a very …

Human malaria is a devastating disease and a major cause of poverty in resource-limited
countries. To develop and adapt within hosts Plasmodium falciparum undergoes drastic …

Abstract Background The malaria parasite Plasmodium falciparum has an unusually
euchromatic genome with poorly conserved positioning of nucleosomes in intergenic …

The highly complex life cycle of the human malaria parasite, Plasmodium falciparum, is
based on an orchestrated and tightly regulated gene expression program. In general …

Gene expression in malaria parasites is subject to various layers of regulation, including
histone post-translational modifications (PTMs). Gene regulatory mechanisms have been …

The genomes of Plasmodium spp. encode a number of different multigene families that are
thought to play a critical role for survival. However, with the exception of the P. falciparum var …

The malaria parasite has a complex life cycle exhibiting phenotypic and morphogenic
variations in two different hosts. Phenotypic cell-to-cell variability can be an important …

Eukaryotic, unicellular parasites of the Plasmodium genus are the causative agents of
malaria. During their life cycle, these parasites alternate between a vertebrate and an insect …

In eukaryotes, cellular differentiation is often orchestrated by programmed arrays of
activation and repression of genes underlying the specific phenotypes of cell-types. To …