Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …

Ageing is characterized by the progressive loss of cellular homeostasis, leading to an
overall decline of the organism's fitness. In the brain, ageing is highly associated with …

Parkinson's disease is predominantly caused by dopaminergic neuron loss in the substantia
nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general …

Even though neurons are post-mitotic cells, they still engage in protein synthesis to uphold
their cellular content balance, including for organelles, such as the endoplasmic reticulum or …

In Alzheimer's disease, reactive oxygen species (ROS) are generated by the deposition of
amyloid-beta oligomers (AβOs), which represent one of the important causes of neuronal …

Abstract Late-onset Alzheimer's Disease (LOAD) is a devastating neurodegenerative
disorder that causes significant cognitive debilitation in tens of millions of patients …

Among the hundreds of nuclear-encoded components of mitochondria that have been linked
to human disease, mutations in the ATAD3 gene cluster have emerged as one of the most …

Frontotemporal lobar degeneration (FTLD) is a common form of early-onset dementia
presenting with a complex gene and pathological architecture. Impairment in several …

Mitophagy is essential for the maintenance of mitochondrial quality control (MQC) and
neuronal survival. Defects in mitophagy have been implicated in the onset and progression …

Parkinson's disease (PD) is one of the most common neurodegenerative diseases and is
pathologically characterized by α-synucleinopathy, which is harmful to dopaminergic …