Mn-based MRI contrast agents: an overview

C Henoumont, M Devreux, S Laurent - Molecules, 2023 - mdpi.com
MRI contrast agents are required in the clinic to detect some pathologies, such as cancers.
Nevertheless, at the moment, only small extracellular and non-specific gadolinium …

Thermodynamic stability of Mn (II) complexes with aminocarboxylate ligands analyzed using structural descriptors

R Uzal-Varela, F Pérez-Fernández, L Valencia… - Inorganic …, 2022 - ACS Publications
We present a quantitative analysis of the thermodynamic stabilities of Mn (II) complexes,
defined by the equilibrium constants (log K MnL values) and the values of pMn obtained as …

Thermal and concentration effects on 1 H NMR relaxation of Gd 3+-aqua using MD simulations and measurements

TJP Dos Santos, AV Parambathu… - Physical Chemistry …, 2022 - pubs.rsc.org
Gadolinium-based contrast agents are key in clinical MRI for enhancing the longitudinal
NMR relativity (r1) of hydrogen nuclei (1H) in water and improving the contrast among …

A seven-coordinate Mn (II) complex with a pyridine-based 15-membered macrocyclic ligand containing one acetate pendant arm: Structure, stability and relaxation …

M Pražáková, D Ndiaye, É Tóth, B Drahoš - Dalton Transactions, 2023 - pubs.rsc.org
A new 15-membered pyridine-based macrocyclic ligand containing one acetate pendant
arm (N-carboxymethyl-3, 12, 18-triaza-6, 9-dioxabicyclo [12.3. 1] octadeca-1 (18), 14, 16 …

Manganese (II) Complex of 1, 4, 7-Triazacyclononane-1, 4, 7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent

MK Islam, AR Baek, BW Yang, S Kim, DW Hwang… - Pharmaceuticals, 2023 - mdpi.com
Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver
disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents …

A systematic investigation of the NMR relaxation properties of Fe (III)-EDTA derivatives and their potential as MRI contrast agents

R Uzal-Varela, F Lucio-Martínez, A Nucera… - Inorganic Chemistry …, 2023 - pubs.rsc.org
We report a detailed investigation of the potential of Fe (III) complexes with H4EDTA
derivatives containing different spacers as magnetic resonance imaging (MRI) contrast …

Development of Macrocyclic Mn (II)− Bispyridine Complexes as pH‐Responsive Magnetic Resonance Imaging Contrast Agents

X Shen, Y Pan, G Liang - European Journal of Inorganic …, 2023 - Wiley Online Library
In this study, macrocyclic complexes of Mn (II) with pH‐responsive relaxivities were
developed. The ligands were based on the rigid MPi platform, which was composed of a …

Isolated spin-pair analysis of 13C NMR relaxation rates in liquids

A Hernández-Tanguma, A Ariza-Castolo - Journal of Molecular Structure, 2023 - Elsevier
In small organic molecules, dipolar relaxation rate R 1 DD is the most important mechanism
for 13 C NMR spin relaxation. Herein, the R 1 DD was used to analyze force-field molecular …

[PDF][PDF] Mn-Based MRI Contrast Agents: An Overview», special issue «MRI Contrast Agents: Current Challenges and New Progresses

C Henoumont, M Devreux, S Laurent - Molecules, 2023 - orbi.umons.ac.be
MRI contrast agents are required in the clinic to detect some pathologies, such as cancers.
Nevertheless, at the moment, only small extracellular and non-specific gadolinium …

Probing the dynamic behaviour and magnetic identification of seven coordinated Mn (ii) complexes: a combined AIMD and multi-reference approach

N Keot, M Sarma - Physical Chemistry Chemical Physics, 2023 - pubs.rsc.org
We present an in-depth solution phase dynamics of rare seven coordinated pentagonal
bipyramidal Mn (II) complexes, together with their binding affinity anticipated using ab initio …