Adhesion G protein–coupled receptors (AGPCRs) are a thirty-three-member subfamily of
Class B GPCRs that control a wide array of physiological processes and are implicated in …

Adhesion G protein-coupled receptors: structure, signaling, physiology, and
pathophysiology Page 1 REVIEW ARTICLE ADHESION G PROTEIN-COUPLED …

RTN4-binding proteins were widely studied as" NoGo" receptors, but their physiological
interactors and roles remain elusive. Similarly, BAI adhesion-GPCRs were associated with …

Chronic pain often leads to depression, increasing patient suffering and worsening
prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically …

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a
disease affecting the somatosensory nervous system. Understanding the pathophysiological …

Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Evidence is emerging that immune responses not only play a part in the central nervous
system (CNS) in diseases but may also be relevant for healthy conditions. We discovered a …

Adhesion G protein‐coupled receptors (aGPCRs) are a class of structurally and functionally
highly intriguing cell surface receptors with essential functions in health and disease. Thus …

Many drugs target the extracellular regions (ECRs) of cell-surface receptors. The large and
alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key …