Radioprotectors are compounds that protect against radiation injury when given prior to
radiation exposure. Mitigators can protect against radiation injury when given after exposure …

Accidental exposure to ionizing radiation is a serious concern to human life. Studies on the
mitigation of side effects following exposure to accidental radiation events are ongoing …

JP4-039 is a lead structure in a series of nitroxide conjugates that are capable of
accumulating in mitochondria and scavenging reactive oxygen species (ROS). To explore …

Currently, more than half of newly diagnosed cancer patients receive radiation treatment.
However, the radioresistance of tumor cells as well as the early and late side effects limit the …

Ionizing irradiation induces acute and chronic injury to tissues and organs. Applications of
antioxidant therapies for the management of ionizing irradiation injury fall into three …

Background/Aim: The earliest cellular and molecular biologic changes in the esophagus that
lead to esophageal cancer were evaluated in a mouse model. We correlated numbers of …

Mitochondrial targeted radiation damage protectors (delivered prior to irradiation) and
mitigators (delivered after irradiation, but before the appearance of symptoms associated …

Background/Aim: Radiation mitigator, GS-nitroxide, JP4-039, was evaluated for mitigation of
total body irradiation (TBI) in Fanconi anemia (FA) Fancd2−/−(129/Sv), Fancg−/−(B6), and …

Purpose To establish and characterize radiation-induced esophagitis (RIE) in vivo and in
vitro. Methods and Materials Fractionated thoracic irradiation at 0, 8, 12, or 15 Gy was given …

Introduction Exposure to low-dose radiation is widespread and attributable to natural
sources. However, occupational, medical, accidental, and terrorist-related exposures remain …