Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively
termed sickness behavior, which while adaptive, can affect mood and cognition. In …

Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …

The central melanocortin system plays a fundamental role in the control of feeding and body
weight. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus …

Diabetes mellitus (DM) has been associated with cognitive complications in the brain
resulting from acute and chronic metabolic disturbances happening peripherally and …

Aims/hypothesis Melanocortin 4 receptor (MC4R) mutation is the most common cause of
known monogenic obesity in humans. Unexpectedly, humans and rodents with MC4R …

The well-documented hormonal disturbance in a general obese population is characterised
by an increase in insulin secretion and a decrease in growth hormone (GH) secretion. Such …

The ventromedial hypothalamic (VMH) nucleus is a well-established hub for energy and
glucose homeostasis. In particular, VMH neurons are thought to be important for initiating …

Hyperphagia and obesity profoundly affect the health of children with Prader–Willi syndrome
(PWS). The Magel2 gene among the genes in the Prader–Willi syndrome deletion region is …

Activation of the hypothalamic–pituitary–adrenal (HPA) axis using an insulin tolerance test
(ITT) is a medical diagnostic procedure that is frequently used in humans to assess the HPA …

Manual acupuncture (MA) can be used to manage high blood pressure; however, the
underlying molecular mechanism remains unknown. To explore the mechanism of …