Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …

Since quinine was first isolated, animals, plants and microorganisms producing a wide
variety of quinolone compounds have been discovered, several of which possess …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

Antibiotic resistance continues to hamper antimicrobial chemotherapy of infectious disease,
and while biocide resistance outside of the laboratory is as yet unrealized, in vitro and in …

Fluoroquinolones are an important class of wide‐spectrum antibacterial agents. The first
quinolone described was nalidixic acid, which showed a narrow spectrum of activity. The …

The peptide antibiotic albicidin is a DNA topoisomerase inhibitor with low-nanomolar
bactericidal activity towards fluoroquinolone-resistant Gram-negative pathogens. However …

Our study confronts the use of antimicrobial agents in ambulatory care with the resistance
trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 …

It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

Background: Multidrug-resistant Escherichia coli (MDR E. coli) has become a major public
health concern in Sudan and many countries, causing failure in treatment with consequent …

Background Antibiotic exposure rapidly selects for more resistant bacterial strains, and both
a drug's chemical structure and a bacterium's cellular network affect the types of mutations …