Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell
compartments, in order to finely adjust key biological routines to the fluctuating metabolic …

The sensu stricto autophagy, macroautophagy, is considered to be both a metabolic process
as well as a bona fide quality control process. The question as to how these two aspects of …

Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical
processes as energy transduction, REDOX signaling, the biosynthesis of hormones and …

Purpose Within this study, we aimed to discover novel gene–disease associations in
patients with no genetic diagnosis after exome/genome sequencing (ES/GS). Methods We …

Sirtuin 3 (SIRT3) deacetylates and activates several mitochondrial fatty acid oxidation
enzymes in the liver. Here, we investigated whether the protein acetylase GCN5 general …

Background Mitochondria play central roles in metabolic diseases including nonalcoholic
steatohepatitis (NASH). However, how mitochondria regulate NASH progression remains …

The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic
status, presenting a heavy burden on society. It is therefore essential to find novel …

Significance: Vascular dysfunction plays a key role in the development of arteriosclerosis,
heart disease, and hypertension, which causes one-third of deaths worldwide. Vascular …

Cells respond to stress in the ER by initiating the widely conserved unfolded protein
response. Activation of the ER transmembrane nuclease IRE1 leads to the degradation of …