Clinical use of anti-histone antibodies in idiopathic and drug-induced lupus
AYS Lee - Immunological Medicine, 2022 - Taylor & Francis
Anti-histone antibodies (AHAs) make their appearance in a number of systemic autoimmune
diseases including systemic lupus erythematosus (SLE) and drug-induced lupus …
diseases including systemic lupus erythematosus (SLE) and drug-induced lupus …
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
Histone post-translational modifications are key gene expression regulators, but their rapid
dynamics during development remain difficult to capture. We applied a Fab-based live …
dynamics during development remain difficult to capture. We applied a Fab-based live …
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome
Mutations in CDCA7, the SNF2 family protein HELLS (LSH), or the DNA methyltransferase
DNMT3b cause immunodeficiency–centromeric instability–facial anomalies (ICF) syndrome …
DNMT3b cause immunodeficiency–centromeric instability–facial anomalies (ICF) syndrome …
Structural features of nucleosomes in interphase and metaphase chromosomes
Structural heterogeneity of nucleosomes in functional chromosomes is unknown. Here, we
devise the template-, reference-and selection-free (TRSF) cryo-EM pipeline to …
devise the template-, reference-and selection-free (TRSF) cryo-EM pipeline to …
Imaging translational and post-translational gene regulatory dynamics in living cells with antibody-based probes
K Lyon, TJ Stasevich - Trends in Genetics, 2017 - cell.com
Antibody derivatives, such as antibody fragments (Fabs) and single-chain variable
fragments (scFvs), are now being used to image traditionally hard-to-see protein …
fragments (scFvs), are now being used to image traditionally hard-to-see protein …
Acetylation of histone H4 lysine 5 and 12 is required for CENP-A deposition into centromeres
WH Shang, T Hori, FG Westhorpe, KM Godek… - Nature …, 2016 - nature.com
Centromeres are specified epigenetically through the deposition of the centromere-specific
histone H3 variant CENP-A. However, how additional epigenetic features are involved in …
histone H3 variant CENP-A. However, how additional epigenetic features are involved in …
The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS
A Shinkai, H Hashimoto, C Shimura… - Nucleic Acids …, 2024 - academic.oup.com
The chromatin-remodeling enzyme helicase lymphoid-specific (HELLS) interacts with cell
division cycle-associated 7 (CDCA7) on nucleosomes and is involved in the regulation of …
division cycle-associated 7 (CDCA7) on nucleosomes and is involved in the regulation of …
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
J Wichmann, C Pitt, S Eccles, AL Garnham… - Cell Death & …, 2022 - nature.com
Histone acetylation is essential for initiating and maintaining a permissive chromatin
conformation and gene transcription. Dysregulation of histone acetylation can contribute to …
conformation and gene transcription. Dysregulation of histone acetylation can contribute to …
[HTML][HTML] A genetically encoded probe for live-cell imaging of H4K20 monomethylation
Eukaryotic gene expression is regulated in the context of chromatin. Dynamic changes in
post-translational histone modification are thought to play key roles in fundamental cellular …
post-translational histone modification are thought to play key roles in fundamental cellular …
Identification of conserved MEL-28/ELYS domains with essential roles in nuclear assembly and chromosome segregation
G Gómez-Saldivar, A Fernandez, Y Hirano… - PLoS …, 2016 - journals.plos.org
Nucleoporins are the constituents of nuclear pore complexes (NPCs) and are essential
regulators of nucleocytoplasmic transport, gene expression and genome stability. The …
regulators of nucleocytoplasmic transport, gene expression and genome stability. The …