Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Purpose: While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the
standard of care in the treatment of many cancers, only a subset of treated patients have …

The key role of interleukin (IL)-23 in the pathogenesis of autoimmune and chronic
inflammatory disorders is supported by the identification of IL-23 receptor (IL-23R) …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

It has recently been demonstrated that in vivo administration of murine interleukin 12 (IL-12)
to mice results in augmentation of cytotoxic natural killer (NK)/lymphocyte-activated killer cell …

A lymphocyte subpopulation, the Vα14 natural killer T (NKT) cells, expresses both NK1. 1
and a single invariant T cell receptor encoded by the Vα14 and Jα281 gene segments. Mice …

▪ Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in
promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its …

Epstein‐Barr virus‐induced gene 3 (EBI3) and the p35 subunit of IL‐12 have been reported
to form a heterodimeric hematopoietin in human and mouse. We have constructed a …

Dihydroxyvitamin D 3 [1, 25-(OH) 2-D 3] is known to be an immunosuppressive hormone.
This review primarily deals with in vitro and in vivo effects of 1, 25-(OH) 2-D 3 and analogue …