Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving
organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical …

Hypothermia therapy is an old and important method of neuroprotection. Until now, many
neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation …

Background—Recent clinical studies have demonstrated that hypothermia to 32° to 34° C
provides significant clinical benefit when induced after resuscitation from cardiac arrest …

There is now compelling clinical evidence from meta-analyses of large randomized
controlled trials that in term infants with moderate to severe hypoxia-ischemia (HI) …

Background and Purpose—The significance of brain temperature to outcome in cerebral
ischemia is recognized. Numerous variations of depth, duration, and delay of cooling have …

Endogenous polyamines profoundly affect the activity of various ion channels, including that
of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that …

The devastating neurologic injury caused by cardiac arrest has been recognized since the
development of modern resuscitation techniques. The persistence of unfavorable neurologic …